1. <computer> Local Integrated Software Architecture.
A personal computer introduced by Apple Computer, Inc. in 1983. The LISA was a predecessor of the Macintosh and was the first personal computer on the market with a graphical user interface.
It was origionally named after Steve Jobs's daughter. The acronym was applied later.
2. <tool> A system for statistical data analysis, similar to S.
3. <event> Large Installation Systems Administration.